830 research outputs found
Photoionization of the fullerene ion C60+
Photoionization cross section of the fullerene ion C60+ has been calculated
within a single-electron approximation and also by using a consistent many-body
theory accounting for many-electron correlations.Comment: 8 pages, 3 figure
Steps toward the power spectrum of matter. II. The biasing correction with sigma_8 normalization
A new method to determine the bias parameter of galaxies relative to matter
is suggested. The method is based on the assumption that gravity is the
dominating force which determines the formation of the structure in the
Universe. Due to gravitational instability the galaxy formation is a threshold
process: in low-density environments galaxies do not form and matter remains in
primordial form. We investigate the influence of the presence of void and
clustered populations to the power spectrum of matter and galaxies. The power
spectrum of galaxies is similar to the power spectrum of matter; the fraction
of total matter in the clustered population determines the difference between
amplitudes of fluctuations of matter and galaxies, i.e. the bias factor. To
determine the fraction of matter in voids and clustered population we perform
numerical simulations. The fraction of matter in galaxies at the present epoch
is found using a calibration through the sigma_8 parameter.Comment: LaTex (sty files added), 31 pages, 4 PostScript figures embedded,
Astrophysical Journal (accepted
The Legacy of Rolf Hagedorn: Statistical Bootstrap and Ultimate Temperature
In the latter half of the last century, it became evident that there exists
an ever increasing number of different states of the so-called elementary
particles. The usual reductionist approach to this problem was to search for a
simpler infrastructure, culminating in the formulation of the quark model and
quantum chromodynamics. In a complementary, completely novel approach, Hagedorn
suggested that the mass distribution of the produced particles follows a
self-similar composition pattern, predicting an unbounded number of states of
increasing mass. He then concluded that such a growth would lead to a limiting
temperature for strongly interacting matter. We discuss the conceptual basis
for this approach, its relation to critical behavior, and its subsequent
applications in different areas of high energy physics.Comment: 25 pages, 5 figures; to appear in R. Hagedorn and J. Rafelski (Ed.),
"Melting Hadrons, Boiling Quarks", Springer Verlag 201
Palaeoproterozoic magnesite: lithological and isotopic evidence for playa/sabkha environments
Magnesite forms a series of 1- to 15-m-thick beds within the approximate to2.0 Ga (Palaeoproterozoic) Tulomozerskaya Formation, NW Fennoscandian Shield, Russia. Drillcore material together with natural exposures reveal that the 680-m-thick formation is composed of a stromatolite-dolomite-'red bed' sequence formed in a complex combination of shallow-marine and non-marine, evaporitic environments. Dolomite-collapse breccia, stromatolitic and micritic dolostones and sparry allochemical dolostones are the principal rocks hosting the magnesite beds. All dolomite lithologies are marked by delta C-13 values from +7.1 parts per thousand to +11.6 parts per thousand (V-PDB) and delta O-18 ranging from 17.4 parts per thousand to 26.3 parts per thousand (V-SMOW). Magnesite occurs in different forms: finely laminated micritic; stromatolitic magnesite; and structureless micritic, crystalline and coarsely crystalline magnesite. All varieties exhibit anomalously high delta C-13 values ranging from +9.0 parts per thousand to +11.6 parts per thousand and delta O-18 values of 20.0-25.7 parts per thousand. Laminated and structureless micritic magnesite forms as a secondary phase replacing dolomite during early diagenesis, and replaced dolomite before the major phase of burial. Crystalline and coarsely crystalline magnesite replacing micritic magnesite formed late in the diagenetic/metamorphic history. Magnesite apparently precipitated from sea water-derived brine, diluted by meteoric fluids. Magnesitization was accomplished under evaporitic conditions (sabkha to playa lake environment) proposed to be similar to the Coorong or Lake Walyungup coastal playa magnesite. Magnesite and host dolostones formed in evaporative and partly restricted environments; consequently, extremely high delta C-13 values reflect a combined contribution from both global and local carbon reservoirs. A C- 13-rich global carbon reservoir (delta C-13 at around +5 parts per thousand) is related to the perturbation of the carbon cycle at 2.0 Ga, whereas the local enhancement in C-13 (up to +12 parts per thousand) is associated with evaporative and restricted environments with high bioproductivity
The Influence of the Second Harmonic in the Current-Phase Relation on the Voltage-Current Characteristic of high TC DC SQUID
A theory for the voltage-current characteristic in high TC DC SQUIDs, which
accounts for a second harmonic in the junction current-phase relation, is
developed. The comparison with experiment is performed. It is shown that if the
second harmonic is prevailed, the theory can explain the large deviations of
the experimental voltage modulation from theoretical predictions and computer
simulations based on conventional sinusoidal current-phase relation.Comment: Eq. 13 is correcte
Mechanical Strength of 17 134 Model Proteins and Cysteine Slipknots
A new theoretical survey of proteins' resistance to constant speed stretching
is performed for a set of 17 134 proteins as described by a structure-based
model. The proteins selected have no gaps in their structure determination and
consist of no more than 250 amino acids. Our previous studies have dealt with
7510 proteins of no more than 150 amino acids. The proteins are ranked
according to the strength of the resistance. Most of the predicted top-strength
proteins have not yet been studied experimentally. Architectures and folds
which are likely to yield large forces are identified. New types of potent
force clamps are discovered. They involve disulphide bridges and, in
particular, cysteine slipknots. An effective energy parameter of the model is
estimated by comparing the theoretical data on characteristic forces to the
corresponding experimental values combined with an extrapolation of the
theoretical data to the experimental pulling speeds. These studies provide
guidance for future experiments on single molecule manipulation and should lead
to selection of proteins for applications. A new class of proteins, involving
cystein slipknots, is identified as one that is expected to lead to the
strongest force clamps known. This class is characterized through molecular
dynamics simulations.Comment: 40 pages, 13 PostScript figure
Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus
Several components of the mosquito immune system including the RNA interference (RNAi), JAK/STAT, Toll and IMD pathways have previously been implicated in controlling arbovirus infections. In contrast, the role of the phenoloxidase (PO) cascade in mosquito antiviral immunity is unknown. Here we show that conditioned medium from the Aedes albopictus-derived U4.4 cell line contains a functional PO cascade, which is activated by the bacterium Escherichia coli and the arbovirus Semliki Forest virus (SFV) (Togaviridae; Alphavirus). Production of recombinant SFV expressing the PO cascade inhibitor Egf1.0 blocked PO activity in U4.4 cell- conditioned medium, which resulted in enhanced spread of SFV. Infection of adult female Aedes aegypti by feeding mosquitoes a bloodmeal containing Egf1.0-expressing SFV increased virus replication and mosquito mortality. Collectively, these results suggest the PO cascade of mosquitoes plays an important role in immune defence against arboviruses
Constraints on the Detectability of Cosmic Topology from Observational Uncertainties
Recent observational results suggest that our universe is nearly flat and
well modelled within a CDM framework. The observed values of
and inevitably involve uncertainties. Motivated
by this, we make a systematic study of the necessary and sufficient conditions
for undetectability as well as detectability (in principle) of cosmic topology
(using pattern repetition) in presence of such uncertainties. We do this by
developing two complementary methods to determine detectability for nearly flat
universes. Using the first method we derive analytical conditions for
undetectability for infinite redshift, the accuracy of which is then confirmed
by the second method. Estimates based on WMAP data together with other
measurements of the density parameters are used to illustrate both methods,
which are shown to provide very similar results for high redshifts.Comment: 16 pages, 1 figure, LaTeX2
High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity
The antigen-binding site of Herceptin, an anti-human Epidermal Growth Factor Receptor 2 (HER2) antibody, was engineered to add a second specificity toward Vascular Endothelial Growth Factor (VEGF) to create a high affinity two-in-one antibody bH1. Crystal structures of bH1 in complex with either antigen showed that, in comparison to Herceptin, this antibody exhibited greater conformational variability, also called “structural plasticity”. Here, we analyzed the biophysical and thermodynamic properties of the dual specific variants of Herceptin to understand how a single antibody binds two unrelated protein antigens. We showed that while bH1 and the affinity-improved bH1-44, in particular, maintained many properties of Herceptin including binding affinity, kinetics and the use of residues for antigen recognition, they differed in the binding thermodynamics. The interactions of bH1 and its variants with both antigens were characterized by large favorable entropy changes whereas the Herceptin/HER2 interaction involved a large favorable enthalpy change. By dissecting the total entropy change and the energy barrier for dual interaction, we determined that the significant structural plasticity of the bH1 antibodies demanded by the dual specificity did not translate into the expected increase of entropic penalty relative to Herceptin. Clearly, dual antigen recognition of the Herceptin variants involves divergent antibody conformations of nearly equivalent energetic states. Hence, increasing the structural plasticity of an antigen-binding site without increasing the entropic cost may play a role for antibodies to evolve multi-specificity. Our report represents the first comprehensive biophysical analysis of a high affinity dual specific antibody binding two unrelated protein antigens, furthering our understanding of the thermodynamics that drive the vast antigen recognition capacity of the antibody repertoire
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